In a novel experiment, a woman with advanced pancreatic cancer saw her tumors dramatically shrink after researchers in Oregon turbocharged her own immune cells. It's not a cure. But the research highlights a possible new way to someday harness the immune system to better fight hard-to-treat cancers. Researchers culled T cells from the woman's blood and genetically engineered them to spot a mutant protein fueling her cancer. The approach failed in a second patient but researchers have begun a small study to more closely test it. The research was published Wednesday by the New England Journal of Medicine.

PESCADERO, Calif. (AP) — Authorities say a quick-thinking custodian safely confined a mountain lion in an empty classroom after it entered a Northern California high school. The San Mateo County Sheriff's Office says no students or staff were at Pescadero High School south of San Francisco yet when the cat strolled onto campus.

UVALDE, Texas (AP) — Mourners gathered Wednesday at a Catholic church to say goodbye to Robb Elementary School teacher Irma Garcia and her husband, Joe. Irma died in the shooting at the Uvalde, Texas, grade school and Joe died two days later from a heart attack after visiting his wife’s memorial. Nineteen children and two teachers were killed May 24 when the 18-year-old gunman burst into their classroom and started shooting.

A gunman carrying a rifle and a handgun killed four people at a Tulsa medical building on a hospital campus, police said, the latest in a series of deadly mass shootings across the country in recent weeks. Wednesday's shooting on the campus of Saint Francis Health System happened the same week that families in Uvalde, Texas, began burying the dead from the deadliest school shooting in nearly a decade.

WASHINGTON (AP) — President Joe Biden on Wednesday acknowledged the strain on families from nationwide shortages of infant formula as he met with manufacturers while his administration tries to address the situation by importing foreign supplies and using the Defense Production Act to speed domestic production.

BUFFALO, N.Y. (AP) — A grand jury Wednesday charged the white 18-year-old accused of fatally shooting 10 Black people at a Buffalo supermarket with domestic terrorism motivated by hate and 10 counts of first-degree murder. Payton Gendron, who has been in custody since the May 14 shooting, is scheduled to be arraigned Thursday in Erie County Court.

The school district police chief who served as on-site commander during last week’s deadly shooting in Uvalde, Texas, says he’s talking daily with investigators, contradicting claims from state law enforcement that he has stopped cooperating. Uvalde Consolidated Independent School District Police Chief Pete Arredondo told CNN in a brief interview Wednesday that he’s speaking regularly with Texas Department of Public Safety investigators. Nineteen children and two teachers died in the attack at Robb Elementary School, the deadliest school shooting in nearly a decade.

LARGO, Fla. (AP) — Police in Florida say a man died searching for Frisbees in a lake at a suburban disc golf course where people are warned by signs to beware of alligators. The Largo Police Department said in an email Tuesday that the unidentified man was looking for Frisbees and other flying discs in the water and “a gator was involved.” No other details of the man’s death were immediately released.

CIENFUEGOS, Cuba (AP) — Like many Cubans before him, Roberto De la Yglesia left most of his family behind when he made his way to the United States with only his son in 2015, hoping that he could soon bring his wife and daughters to join him. Years later, the mechanical engineer in New Jersey and his family back in Cienfuegos, Cuba, are still waiting — with a mixture of renewed hope and skepticism.

WASHINGTON (AP) — A federal judge in Washington is set to preside over an important hearing for the man who shot President Ronald Reagan more than 40 years ago. John Hinckley is set to be released from restrictive conditions he has lived under since he shot Reagan and several others in 1981.

UVALDE, Texas (AP) — The blame for an excruciating delay in killing the gunman at a Texas elementary school — even as parents outside begged police to rush in and panicked children called 911 from inside — has been placed with the school district’s homegrown police chief. It’s left residents in small city of Uvalde struggling to reconcile what they know of the well-liked local lawman after the director of state police said that Pete Arredondo — as the commander at the scene — made the “wrong decision” last week not to breach a classroom at Robb Elementary School sooner.

UVALDE, Texas (AP) — It should have been the first day of a joyous week for Robb Elementary School students — the start of summer break. Instead on Monday, the first two of 19 children slain inside a classroom were being remembered at funeral visitations.

SANTA FE, N.M. (AP) — As more than 3,000 firefighters in northern New Mexico continue to battle the nation’s largest active wildfire, federal forest officials are worrying about future flash floods, landslides and destructive ash from the burn scar. The 7-week-old fire is the largest in New Mexico history.

ATLANTA (AP) — Hundreds of flights worldwide were canceled by mid-afternoon Sunday, adding to the mounting number of scrubbed flights during the busy Memorial Day holiday weekend. About 1,460 flights had been canceled as of 7 p.m. EDT Sunday, according to flight tracking website FlightAware.

WEYBRIDGE, Vt. (AP) — The remains of a Revolutionary War soldier were moved this Memorial Day weekend to another resting place in Vermont because erosion threatened some of the graves at an old cemetery near a river bank.

UVALDE, Texas (AP) — The Justice Department said Sunday it will review the law enforcement response to the Texas school shooting, an unusual federal look back prompted by questions about the shifting and at times contradictory information from authorities that have enraged a community in shock and sorrow.

TAFT, Okla. (AP) — Authorities said a 26-year-old man was in custody after one person was killed and seven people were injured in a shooting early Sunday at an outdoor festival in eastern Oklahoma, where witnesses described frantic people running for cover amid gunfire.

HONOLULU (AP) — The Navy says newly analyzed documents show 13 World War II sailors previously believed to have been unaccounted for after a Japanese submarine torpedoed their ship were actually buried at sea. The sailors were from the USS Indianapolis, which was sunk by Japanese torpedoes on July 30, 1945.

COLUMBUS, Ohio (AP) — New exhibits at museums in Ohio and California are celebrating the upcoming centenary of the birth of Charles “Sparky” Schulz, the man who created the comic strip Peanuts.

UVALDE, Texas (AP) — Authorities say children repeatedly called 911 from inside a Texas elementary school where a gunman killed 19 students and two teachers, including a girl who told the dispatcher “Please send the police now." Steven McCraw, the director of the Texas Department of Public Safety, said at a news conference Friday that teachers and students repeatedly called 911 during Tuesday’s attack at Robb Elementary School in Uvalde. He says police were at the scene for at least an hour before U.S. Border Patrol agents used a master key to open a locked classroom door. He says the agents then killed the gunman, 18-year-old Salvador Ramos, at about 12:50 p.m.

The family of a fourth grade teacher was already reeling from her death in the school shooting that targeted her classroom in Uvalde, Texas. Then, just two days after Irma Garcia was killed, her grieving husband collapsed and died at home from a heart attack.

LOS ANGELES (AP) — To drive, or not to drive? This Memorial Day weekend, with surging gas prices that are redefining pain at the pump, that is the question for many Americans as a new COVID-19 …

UVALDE, Texas (AP) — Texas authorities say the gunman who massacred 21 people at an elementary school was in the building for over an hour before he was killed by law enforcement officers. The amount of time that elapsed has stirred anger and questions among family members, who demanded to know why authorities did not storm the place and put a stop to the rampage more quickly.

HONOLULU (AP) — Many hotels across the United States have done away with daily housekeeping service, making what was already one of the toughest jobs in the hospitality industry even more grueling.

WASHINGTON (AP) — The White House has announced more steps to make the antiviral treatment Paxlovid more accessible across the U.S. as it projects COVID-19 infections will continue to spread over the summer travel season.